Cavity Guard

Targets key stages of the caries process – Advanced Defence Cavity Guard

LISTERINE® Advanced Defence Cavity Guard delivers 450ppm of fluoride,2 strengthening the enamel considerably more than fluoridated toothpaste alone.3*

Alcohol-free Advanced Defence Cavity Guard manages the caries risk factors identified in the Keyes concept.1 This is achieved through multiple mechanisms configured to offer an integrated approach to caries prevention.2–5

With efficient delivery of 450ppm fluoride,2 it reinforces teeth effectively, strengthening the enamel considerably more than fluoridated toothpaste alone.3* Advanced Defence Cavity Guard also delivers an unsurpassed reduction in plaque.4 Furthermore, in residual plaque, it represses acid production significantly.5$


Mean fluoride concentration (μg F/cm3) in enamel in vitro2

Adapted from an in vitro study: fluoride content 20 days, DOF 3 – 2013.2 18 sound human incisors were evaluated per arm.


Increase in enamel strength (micro hardness) versus baseline at 5, 10, 20 days in vitro3, and post acid challenge in vitro6

*in vitro

† Compared to other alcohol-free daily rinses, in vitro

§ Compared to water, in vitro

pathogenic plaque bacteria

Plaque bacteria are an important risk factor for caries and in an in vitro study of a plaque biofilm model, Advanced Defence Cavity Guard reduced plaque bacteria levels by 99%4.

Production in residual plaque

In an in vitro study, LISTERINE® Advanced Defence Cavity Guard demonstrated the repression of acid production in residual plaque. In this study, biofilms were grown for 48 hours, then treated with 1.8 ml of test rinse for 5 minutes, followed by a 3-fold rinse with cysteine peptone water.1


  1. Van Loveren C et al. European Journal of Nutrition 2012; 51(2S): 15–25.

  2. Fluoride content 20 days, DOF 3 – 2013.
  3. Surface microhardness, DOF 4 – 2013.
  4. Reduction in plaque biofilm, DOF 6 – 2013.
  5. Plaque biofilm acid production, DOF 7 – 2013.

  6. SMH plaque acid challenge, DOF 5 – 2013.